'affekten'         

D ansk
S elskab for
A ffektive
L idelser

 

 

 

 

 

Symposium fredag 8. maj 2015

Depressionens mange ansigter

 

 

 

 

 

 
     
 

Programmet startede
med overrækkelse af
'affekten' til Jesper Krogh.

Han fik prisen for artiklen
nedenunder.

 

 

 

 

 

 

Jesper Krogh    

Krogh, J., Rostrup, E., Thomsen, C., Elfving, B., Videbech, P., & Nordentoft, M. (2014). The effect of exercise on hippocampal volume and neurotrophines in patients with major depression--a randomized clinical trial. Journal of Affective Disorders, 165, 24-30.
BACKGROUND: The hippocampal volume is reduced in patients with major depression. Exercise leads to an increased hippocampal volume in schizophrenia and in healthy old adults. The effect of exercise on hippocampal volume is potentially mediated by brain derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and insulin like growth factor 1 (IGF-1). The aim of this trial was to assess the effect of an aerobic exercise intervention on hippocampal volume and serum BDNF, VEGF, and IGF-1 in patients with major depression. METHODS: Patients were randomized to an aerobic exercise intervention (n=41) or a control condition (n=38). Both interventions consisted of three supervised sessions per week during a three months period. RESULTS: Post-intervention the increase in maximal oxygen uptake was 3.90 ml/kg/min (SD 5.1) in the aerobic exercise group and 0.95 ml/kg/min (SD 6.2) in the control group (p=0.03). The hippocampal volume, BDNF, VEGF, or IGF-1 did not differ between the two groups. Post-hoc we found a positive association between change in hippocampal volume and verbal memory (Rho=0.27; p=0.05) and change in hippocampal volume and depressive symptoms (Rho=0.30; p=0.03). LIMITATIONS: Participation was low in both groups corresponding to an average participation of one session per week. CONCLUSION: Despite a significant increase in maximal oxygen uptake, a pragmatic exercise intervention did not increase hippocampal volume or resting levels of neurotrophines in out-patients with mild to moderate major depression.
Trial identifier: ClinicalTrials.gov (NCT00695552)

 
Auditorium 61A på RH: pænt fremmøde    
   
     

Poul Videbech

Den behandlingsresistente depression

 
     
 

Martin Balslev Jørgensen

Den anxiøse depression

 
 

 

Ida Hageman

Den årstidsbestemte depression

 

 

 

 

 

 

 
     

Svend Åge Madsen

Den mandlige depression

 

 

 

 

 

 

 

 

 

 

 

 
     
     
 

Søren Dinesen Østergaard

Den psykotiske depression

 

 

 

 

 

 

 

 

 

 

 

 

 

     
     
 

Jens Bukh

Core depression, den ægte depression?

 

 

 

 

 

 

 

 

 

 

 

     
 

 

Foto: Anders Gade, Institut for Psykologi, KU