Brown, J., Gydesen, S., Johannsen, P., Gade, A., Skibinski, G., Chakrabarti, L.,
Brun, A., Spillantini, M., Yancopoulou, D., Thusgaard, T., Sorensen, A., Fisher, E., &
Collinge, J. (2004). Frontotemporal dementia linked to chromosome 3. Dementia and
Geriatric Cognitive Disorders, 17, 274-276.
Adr: Department of Neurology, Addenbrooke's Hospital, Cambridge, UK. firstname.lastname@example.org
A large pedigree with autosomal dominant frontotemporal dementia has been identified. Positional cloning has linked the disease gene to the pericentromeric region of chromosome 3. Clinical, neuropsychological, imaging, pathological and molecular genetic data are presented. The genetic mutation responsible for the disease has not been identified.